I’m taking a backpack over, which has a detachable daypack. But I’m also taking a small over-the-shoulder handbag. It’s only fairly small, enough for a wallet and camera, but it also zips up and has a buttoned flap over the zip. But I figure it will be handy for going to clubs at night etc (I’d look like a goose with a daypack in a club lol). I figure the small handbag will be good for some days out, but then days I need more stuff (water botlle, jumper etc) I’ll take the daypack. Plus I’m going with my bf, so we can always share a daypack between us if we want. I also have some combination locks so if i’m carrying the daypack somewhere dodgy I can lock up the zippers.
On my last trip (mind you, this was only to UK/Ireland - perhaps less pickpockety?) I took a suitcase, and a larger over-the-shoulder handbag. This bag was also great as I didn’t look too touristy, and it was a decent size to fit lots of stuff and it zipped up.
I’ve never bothered with fancy pacsafe bags because of the price. I’m sure they’re good. But I think the main thing is just be careful and use common sense and you’ll be ok. And spread your money/cards/passport copies across your different bags, so if you do lose something you have a good backup plan!